I just changed HDD in my computer last night.Put 2 known working HDDs from my main system in my studio computer which I have had no problems with at all.
Everything worked,burned a CD and everything.Used it this afternoon,and still worked great.Tonight I booted it up,and got a BSOD,missing VXD,and then the 2nd IDE controller not working.Can't access the burner,but I can access the second HDD.

Thinking that it was a windows probelm, I reinstalled over the OS,and still no change.I formatted again and reinstalled 98SE,instead of ME,and still same thing.
It will list the HDDs and CDs during bootup,and will find them in the BIOS.It lists C,D,E in the explorer,and F as a removable disk(CD-RW)The burner is also redflagged in the Device manager,and a yellow (!) by the 2nd controller.
The IDE is enabled in the BIOS as well.
Windows 98SE
Amptron 8400c MOBO
400MHZ K6/2
Virge 3d 4mb PCI Video
6.1 and 4.3 WD Caviar HDDs
Teac CD-ROM Mitsumi CD-RW
Modem
128 MB PC133
Is this MOBO on the way out?
<edit Spullin>