ok if using a hole saw follow these basic rules to keep from destroying your window.
remove the window and use heavy masking tape, (NOT duct tape) to fully cover the side you will be drilling on then cover the area on the other side where the hole will be drilled through to with tape as well, then tape a couple "buffer" layers of newspaper to that side as well.
make sure where your doing this is not too cold, as that will make the acrylic brittle and increase any chance of cracking.
you want to preferably use a drill press and not a just a hand held electric drill.
use something just larger than your window and rigid... (preferably wood that you dont mind drilling into) to support and backup the window.
drill very slowly and back it off and up often, to make sure you dont "burn" through it instead of cut through it... acrylic tends to melt and get gooey and will make for an unclean hole...
when going through last bit before breaking through, be especially slow and careful.
when done use a razor blade or cutting tool to trim the inside edges and I run high grit wet/dry "finishing" sandpaper inside to smooth off.
Dont forget to lay out and drill the screw holes as well ...following the same steps for the hole. I personally use a very slightly larger drill than needed, and I use clear soft washers on outside (at head of screw) and between the fan and the window to buffer the fan and reduce vibration and reduce risk of cracking the acrylic.
good luck and take your time... if you rush or cut corners you will regret it.