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No, I wouldn't do anything like that regardless of use. The only time I would disconnect the fan is if I took the CoolBits reg hack or Powerstrip and cranked the clock speeds waaaay down, as far as they would go, which would could possible reduce heat enough to where no fans were needed.
Try it and see, the worst that would happen is your comp would freeze. If it does, reconnect the fan and check into other options.
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