well, it won't make a difference if your processor's FSB speed is SLOWER than your ram.
If you don't ever upgrade the processor, then whichever speed of ram matches your processor's FSB is fine.
By the way, what kind of system is it for?
My athlon xp1800 has a 266mhz FSB and I have PC2700 ram which is 333mhz, whereas the PC2100 is 266mhz.
So, technically I really don't need the PC2700. I just bought it to be upgrade safe.