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Is this the hard drive you're trying to boot from? You can't just swap one drive for another without reformatting or reinstalling windows and not have any problems, unless it's from an absolutely identical computer.
But that's probably beside the point, because since the BIOS loads before the OS, no software should be able to interfere with your ability to access the BIOS.
I'd just keep hitting DEL over and over again immediately after you power on, until either you see the BIOS screen or a Windows load screen. I'd also try clearing the CMOS, and yes, check to see if the keyboard is plugged all the way in, or try another keyboard. Some USB keyboards won't work before windows loads if they're not enabled in the BIOS.
Good luck.
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