What is the homepage that is in question?
Just running spybot will not get it. You need adaware, cwshredder, antivir and hijackthis to properly clean, as well as spybot. Even then there might be something missed, ive manually cleaned up a few after all that.
Run them in that order. Do a google search on the names as I posted them to find the programs. A little homework.

Google is your friend.