Yes, you can. Simply install the card and drivers, and reboot.
Right click the wallpaper, go to properties, click settings.
Should have three monitors in the window.
Select each one in the pop up tab, and check Extend my desktop unto this monitor.
This setting should be 'independent" mode. There is also Spanning, across all three monitors, and Cloning, all monitors display the same thing.
The only combo of multi monitors that will not work is onboard and AGP card. The onboard uses the AGP bus, and disables the onboard vid as soon as an AGP card is installed.