I would not count on WINE. Wine can work sometimes. If you want an easily configurable version get codeweavers wine,
www.codeweavers.com
That being said, I would use linux alternatives if possible. There are plenty of functional and useful alternatives. Some applications you may need, I use crossover office as MS office makes it MUCH easier for me to type in a foreign language and set my own keybindings. It also doesnt freeze when I print like some other office suite.
What applications do you plan on using from windows?