Yes it can be done, but it can be nearly impossible.
If you are lucky, a hammer and screwdriver will be sufficient persuasion. You won't be that lucky.
You may ba able press them out successfully with a C-clamp and a couple of sockets. If you can take the springs fully off the vehicle, a bench vise also works.
If these fail, then burn them out with a torch. This is a smelly, nasty mess, but works almost every time. Adequate ventilation is a must -- and don't drip molten rubber on concrete you care about.
Some bushings are vulcanized to an outer metal sleeve which must be cut and pounded out.
When the bushings are out, use emery cloth to clean any left over rubber or metal fragments out of the spring eye.
If you are using polyurethane replacement bushings, be sure to grease them up with the manufacturer-provided grease or regular heavy bearing grease. You may need to use the C-clamp (or bench vise) and sockets to force the new bushings into the spring and frame eyes.
If you can replace the bushings without having to remove the springs, then you can get away with not getting the alignment. But once you remove the springs and axle, an alignment will be in order to make sure everything is straight.